A struggling comedy duo discovers that surviving the apocalypse is almost as difficult as surviving in Hollywood. When all power and communication systems mysteriously shut off, the unprepared couple pack up their things and hit the road in search of a safe haven to wait out the possible extinction event. Accompanied by their trusty dog Watson and their miserable cat Mrs. Peel, the duo must struggle against the mundane realities of the collapse of civilization while retaining their decency and rationality as the rest of humanity starts getting really, really weird.