Meet Franklin Hart. The biggest "sexist, egotistical, lying, hypocritical bigot" boss on the planet. He thrills in taking advantage of his head female office staff; humiliating, downplaying, and condescending against them whenever conveniently possible, particularly his top assistant Violet. Long-exhausted over his gruesome bullishness, Violet, alongside co-workers Doralee and Judy comprise comical methods of "doing him in", when a freak incident occurs. They then manage to kidnap Hart and trap him in his own house, while assuming control of his department, and productivity leaps. But just how long can they keep him tied up?
Paranoid Brigadier General Jack D. Ripper of Burpelson Air Force Base, believing that fluoridation of the American water supply is a Soviet plot to poison the US. populace, is able to deploy through a back door mechanism a nuclear attack on the Soviet Union without the knowledge of his superiors, including the Chair of the Joint Chiefs of Staff, General Buck Turgidson, and President Merkin Muffley. Only Ripper knows the code to recall the B-52 bombers and he has shut down communication in and out of Burpelson as a measure to protect this attack. Ripper's executive officer, RAF Group Captain Lionel Mandrake (on exchange from Britain), who is being held at Burpelson by Ripper, believes he knows the recall codes if he can only get a message to the outside world. Meanwhile at the Pentagon War Room, key persons including Muffley, Turgidson and nuclear scientist and adviser, a former Nazi named Dr. Strangelove, are discussing measures to stop the attack or mitigate its blow-up into an all.
When the aging head of a famous crime family decides to transfer his position to one of his subalterns, a series of unfortunate events start happening to the family, and a war begins between all the well-known families leading to insolence, deportation, murder and revenge, and ends with the favorable successor being finally chosen.